BRD4 and atrial fibrillation: Our results indicate that mechanisms by which LMNA variants may drive AF include genotoxic stress and alteration of the microtubule network, as the BRD4 inhibitor RVX-208 prevented the arrhythmogenic effect of TP in Drosophila WT- and p.R264Q-expressing strains, and microtubule stabilizer taxol similarly protected against arrhythmogenicity in WT- and p.N210K-expressing strains.