Notably, in 50% of individuals carrying LMNA variants, the onset of AF precedes the development of dilated cardiomyopathy or other ventricular arrhythmic-related cardiomyopathies by several years (Captur et al., 2018; Kumar et al., 2016; van Berlo et al., 2005), indicating that LMNA variants drive AF. Here, LMNA is linked to atrial fibrillation.