In contrast, USP10 also exerts a tumor suppressive role in lung cancer and in colorectal cancer via modulating the ubiquitin of KLF4 and ZEB1.[22, 25] Based on these findings, we can conclude that the effects of USP10 on cancer malignant behaviors are context‐specific, and always depends on the key protein substrates that regulated by USP10‐mediated deubiquitination. This evidence concerns the gene KLF4 and lung cancer.