In this study, USP10 was determined to be a potential ferroptosis regulator, which was in agreement with the genome‐wide CRISPR screen system reported by Zou Y et al.[39] Gene gain and loss of functional experiments confirmed that USP10 suppressed ferroptosis via a SLC7A11‐dependent way in HNSCC, not through other pathways (DHODH and FSP1). Here, USP10 is linked to head and neck squamous cell carcinoma.