As a member of USPs, USP10 is involved in cancer progression via the modulation of protein substrates in multiple cancer types.[20, 21, 22, 23, 24, 25, 26, 27, 28] It is abnormally expressed in solid cancers, such as ovarian cancer, gastric carcinoma, colorectal cancer, prostate cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma and glioblastoma etc. In addition, its overexpression or downregulation correlated with cancer prognosis depending on cancer types.[20, 21, 22, 23, 24, 25, 26, 27, 28] However, its roles in HNSCC and cancer ferroptosis remain unclear. The gene discussed is USP10; the disease is head and neck squamous cell carcinoma.