Combined with the usage of Imidazole ketone erastin (IKE, an Erastin analog with a more potent, selective and stable inducer of ferroptosis), an obviously synergistic tumor inhibitory effect was observed in mice treated by USP10 depletion plus IKE, which was manifested by the tumor growth pattern (Figure3A,B), harvested xenografted tumors (Figure 3C,D) and tumor weight (Figure 3E,F) and cell proliferation marker Ki67 and lipid peroxidation marker 4‐hydroxy‐2‐nonenal (4HNE) (Figure S5, Supporting Information). Here, USP10 is linked to neoplasm.