POLR2A and cancer: It has been reported that p53 inhibits cystine uptake and sensitizes cells to ferroptosis by repressing expression of SLC7A11.[45] In contrast, as a neighboring gene of TP53 that co‐localize in the Chr17p region, POLR2A functions in a totally opposite way to transcriptionally activate SLC7A11, hence repressing ferroptosis of cancer cells.