There are three major cellular protective systems against ferroptosis including GPX4, FSP1, and DHODH.[32] To clarify through which system USP10 regulates cancer ferroptosis, USP10‐depleted and control Fadu cells were subjected to RNA‐seq, which clearly showed that SLC7A11, an upstreaming regulator of GPX4, was significantly declined in UPS10‐depleted Fadu cells (Figure4A; Table S5, Supporting Information). Here, DHODH is linked to cancer.