USP10 and head and neck squamous cell carcinoma: In addition, USP10 overexpressed in HNSCC Cal27 cells (Figure 4D; Figure S6A,B, Supporting Information), and we found that SLC7A11 mRNA, proteins of SLC7A11 and GPX4 were correspondingly elevated, while GPX4 mRNA, mRNAs and proteins of FSP1 and DHODH still remained at the same level (Figure 4D,E).