We used data from the Avon Longitudinal Study of Parents and Children (n = 4745) on ACEs (from birth to age 8 years), LUTS at age 14 years [any urinary incontinence (UI), daytime and bedwetting, urgency, nocturia, frequent urination, voiding postponement, and low voiding volume], and inflammatory biomarkers interleukin-6 (IL-6) and C-reactive protein (CRP) measured at age 9 years. The gene discussed is CRP; the disease is Urinary incontinence.