No differences were observed for the other MS parameters and for CRP at both 3- and 6-month follow-up.<h4>Conclusions</h4>Periodontal treatment seems to have beneficial effects on SBP and FBG in patients with MS and periodontitis at 3-6-month follow-ups.<h4>Trial registration</h4>This systematic review was registered under the protocol registration number CRD42024499854/PROSPERO. This evidence concerns the gene CRP and myeloid sarcoma.