In the metastasis group, the top shared upregulated genes were cancer-related with diverse functions, including tumor suppressors (SAMD9 and SEMA3B) and genes involved in growth, survival, cytoskeletal dynamics, motility, invasion, and metastasis (RHOBTB3, CYP24A1 and PTGS2). The gene discussed is RHOBTB3; the disease is cancer.