IL18 and cancer: Taken together, inducing pyroptosis is an effective approach to trigger a cascade of events in the cancer-immunity cycle, the steady-state switching mediated by the AV-EVLPs via silencing immunosuppressive IL-1β-driven pathways and amplifying IL-18-mediated antitumor immunity might reshape the TME from an immunologically “cold” into a “hot” phenotype, while this hypothesis remains to be verified through experiments in the follow-up study.