ANKRD17 and Anxiety: Case 2 involves a 12-year-old male with mild ID and progressive social impairments, associated with a de novo NM_032217.5: c.1252 C > T (p.Arg418*) variation in ANKRD17. Additionally, we performed behavioral experiments using Ankrd17-deficiency mice, which mimic impaired social interaction, elevated anxiety, and compromised spatial learning memory.