Regarding its metastatic potential, MTHFD2 appears to promote the epithelial-mesenchymal transition by upregulating vimentin and N-cadherin, where MTHFD2 depletion has been shown to impair the organization of the vimentin network required for cell motility and migration in breast cancer cells15 and in renal cancer32. This evidence concerns the gene MTHFD2 and breast carcinoma.