TOP2A is required for mitotic chromosome condensation62 and DNA replication and repair63, and since the topoisomerase 2 inhibitor etoposide is widely used in clinics as a chemotherapeutic agent in combinatorial therapies in lung cancer64, breast cancer65, prostate cancer66 and lymphoma67, among other cancer types, the combinatorial inhibition of MTHFD2 and topoisomerase 2 could become a potential cancer therapeutic approach. The gene discussed is TOP2A; the disease is cancer.