MTHFD2 and hepatocellular carcinoma: Conversely, MTHFD2 can also be activated by β-catenin in hepatocellular carcinoma, where MTHFD2 was found to mediate the oncogenic function of nucleoside diphosphate kinase 7 (NME7), which induces the Wnt/β-catenin pathway that activates MTHFD2 expression28.