Sanchez-Garrido et al. have already shown that paternal HFD exacerbates the magnitude of HFD-induced hypogonadism in F1 males, affecting the expression of star, hsp11 and hsd-17β50, despite the authors did not investigate the activity of cyp19a1 nor the methylation pattern of its genetic locus. The gene discussed is CYP19A1; the disease is hypogonadism.