Taking these parameters and inter-relationships together, it is noteworthy that smaller tumor compartments, higher densities of CD4 and CD8 T cells, and shorter distances among CD4 T cells, between CD8 and CD56 cells and among CD68 cells were all positively associated with longer survival, whereas shorter distances between CK cells and CD68 cells, CD4 T cells, or other CK cells were negatively associated with longer survival. The gene discussed is CD8A; the disease is neoplasm.