In pancreatic cancer, CAFs near the cancer cells exhibit a myoCAF phenotype with high TGF-β-driven α-SMA expression and lower levels of IL-6 (α‐SMAhighIL‐6low), while the more peripheral CAFs have lower αSMA expression with higher levels of IL-6 (α‐SMAlowIL‐6high) consistent with iCAFs74. The gene discussed is ACTA1; the disease is familial pancreatic carcinoma.