AICDA and cancer: As AID and its paralogues from the APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic subunit 3) family of cytidine deaminases are prominent genome mutators33,34we propose that FAM72A contributes to mutagenic repair of dUs introduced by the AID/APOBEC3 enzymes, thus playing a role in cancer mutagenesis through a cytosine deamination-dependent mechanism.