In addition, several studies have reported that ΔNp63 is the main isoform of p63 that acts as both an oncogene and a tumor suppressor, especially during EMT progression15,16,26,27; Therefore, we examined the effect of ΔNp63 downregulation on the proliferation, migration, and invasion capacities of HeLa and CaSki cells. This evidence concerns the gene TP63 and neoplasm.