A study conducted in 2016100 revealed that the activated oncoprotein p53 facilitates the progression of metastatic tumors through downstream effectors, including ENTPD5, an ER UDPase that plays a role in the calnexin/calreticulin cycle, a critical process involved in the proper folding and maturation of N-glycoproteins, which are essential for various cellular functions. This evidence concerns the gene ENTPD5 and metastatic neoplasm.