These findings uncover a potential reciprocal negative feedback loop between FGFR3-TACC3 and IFN-γ signaling in luminal-type BC cells, wherein constitutive activation of FGFR3 signaling inhibits the IFN-γ pathway [26]; while IFN-γ suppresses FGFR3-TACC3 transcription through PD-L1 induction. The gene discussed is TACC3; the disease is breast cancer.