FGFR3-TACC3 fusions are generated by intrachromosomal rearrangements of FGFR3 on chromosome 4p16, which lead to the loss of an miR-99a binding site within the 3′-untranslated region of FGFR3 and enhance tumor progression compared to wild-type FGFR3 [28, 29]. This evidence concerns the gene FGFR3 and neoplasm.