PPARGC1A and colorectal carcinoma: To further confirm that PGC1α inhibits CRC cell proliferation by regulating the Warburg effect, CRC cells were overexpressed or knocked down for PGC1α and treated with varying concentrations of 2-DG (0, 2, 4 mM) for 48 h, and the lactate production levels and proliferation ability of the CRC cells were evaluated.