Likewise, 13 out of 20 hub genes (AQP8, CA2, CDHR2, CLCA1, FCGBP, GUCA2A, HMGCS2, MOGAT2, PGC1α, SLC4A4, SLC9A2 SLC26A3, and ZG16) were downregulated and were associated with a poor prognosis in CRC. The gene discussed is HMGCS2; the disease is colorectal carcinoma.