PPARGC1A and colorectal carcinoma: Initially, we found that DNMBP-AS1 downregulation significantly suppressed PGC1α and overexpressed PKM2 in CRC cells, whereas miR-30a-5p inhibition partially reversed the regulatory effect of DNMBP-AS1 knockdown on PGC1α and PKM2 expression; Strikingly, neither LDHA nor HK2 expression exhibited responsiveness to these perturbations of the ceRNA network (Fig. 6A).