More than 80% of AML cases express insulin receptor isoform A and insulin-like growth factor 1 receptor (IGF1R), two tyrosine kinases transducing signaling through the AKT serine/threonine kinase 1 and mitogen-activated protein kinase kinase (MEK)1/2 pathways and supporting survival under serum starvation in leukemic cells [86]. Here, IGF1R is linked to acute myeloid leukemia.