Treatment of the Jurkat cell line with a spermidine analog led to downregulation of epigenetic modulators such as histone deacetylase HDAC1 and HDAC3, DNMT1 and lysine demethylases (KDM3A, KDM4B, and KDM4C) [42], suggesting a link between polyamines and methylation also in T-ALL. This evidence concerns the gene HDAC1 and acute lymphoblastic leukemia.