DNMT3A and acute myeloid leukemia: In AML, activation of NRF2/NQO1 is also mediated by DNA methytransferase 3A (DNMT3A)R882H mutation [92], which impairs both the CpG methylation efficiency and the specificity of DNMT3A [93], suggesting a potential link between polyamine deregulation and altered DNMT3A activity.