Two ODC1 and one SMOX mutations were identified across 1214 AML from the TCGA-LAML, Beat AML, AML TARGET (https://www.cbioportal.org/) and our NGS-PTL (EGAD00001007940, EGAD00001007941) [9, 10] cohorts, and 153 B-ALL and 72 ALL (not otherwise specified) from the St. Here, ODC1 is linked to acute lymphoblastic leukemia.