Still, because endogenous glucocorticoids are involved in a well-balanced circadian rhythm32, and given a dysregulated circadian rhythm not only disturbs immune functioning but also contributes to MASLD and cardiovascular disorders, GR-targeting agents should be either novel generation molecules with a narrow activity spectrum or exhibit a unique profile following crosstalk mechanisms with other nuclear receptors, to only target those activities that are of benefit within the specific pathology of MASLD33,34. This evidence concerns the gene NR3C1 and metabolic dysfunction-associated steatotic liver disease.