Brain water content increased in acute AVP- and dDAVP-induced hyponatremia (respectively to 79.52% ± 0.11, n = 6 and to 79.40% ± 0.09, n = 6 vs. 78.36% ± 0.11 in Sham, n = 6, p < 0.001). This evidence concerns the gene AVP and Hyponatremia.