To exclude the potential direct impact of IFNγ on the tumor growth, after Rag2–/–γc–/– mice were fed on LFD, palm oil HFD, or olive oil HFD for 30 days, the mice received an intraperitoneal injection of either anti-IFNγ mAb or rhIFNγ after 7 days of GFP+ A549 tumor cells inoculation (Supplementary Fig. 9a). The gene discussed is RAG2; the disease is neoplasm.