IFNG and neoplasm: We further clarified a novel underlying mechanism linked to the functional defects of Vγ9Vδ2-T cells caused by PA, whereby PA stimulated Vγ9Vδ2-T cells to secret excess IFNγ, which in turn induced cell pyroptosis, caused functional and metabolic defects, and ultimately led to the defective capacity of Vγ9Vδ2-T cells against tumor cells.