Narrowing this analysis to genes located only in regions with focal prognostic value as determined by focal increases in AUC across 200 Kb bins identified NUAK2 as important for LFFR (AUC 0.61), and NUAK2, DSP, and PRKAR2B as most important for OS (AUC 0.72) (Supplementary Fig. 5d), suggesting that these genes may drive the prognostic value of their respective CNAs in meningioma. Here, PRKAR2B is linked to meningioma.