CYCS and Krabbe disease: Use of the direct nondestructiveRaman microspectroscopy allowed quantification of the effect of thefibrils on the mitochondrial redox state, as evidenced by an oxidationof cytochrome c, which is indicative of mitochondrialdysfunction and apoptosis initiation, supporting the hypothesis thatGalSph-induced mitochondrial dysfunction plays a central role in drivingcell death in GLD.