Recent studies have shown that cortical hyperexcitability and glutamate excitotoxicity, both observed in ALS, induce TDP-43 translocation into the cytoplasm (Boussicault et al, 2020; Weskamp et al, 2020; Dyer et al, 2021; Berthiaume et al, 2024). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.