The presence of TDP-43 aggregates in motor neuron cytoplasm has also been reported in SOD1-associated ALS patients (Mackenzie et al, 2007; Tan et al, 2007) and in spinal cord of SOD1 mice model from the symptomatic stage (Okamoto et al, 2011; Jeon et al, 2019). Here, SOD1 is linked to amyotrophic lateral sclerosis.