MAPT and Alzheimer disease: For example, post-mortem CSF in people with autopsy-confirmed with CTE showed elevated p-tau concentrations in individuals with no AD pathology compared to AD controls.61 Furthermore, quantification of p-tau levels within frontal tissue in patients with CTE, AD, CTE with AD and controls showed a significant decrease in p-tau181 in CTE versus controls, increased p-tau231 and p-tau396, as well as increased p-tau202, which related to the years of RHI exposure.