The common causes of SMVT include hypercoagulable states (Antiphospholipid antibodies, Deficiencies of Antithrombin III, protein C or S, pregnancy, OCPs), malignancy, recent surgery, inflammatory conditions (pancreatitis, inflammatory bowel disease), portal hypertension, etc. Suppurative pylephlebitis is another rare cause of SMVT, mostly following acute appendicitis or its sequelae, acute diverticulitis, and intra-abdominal abscess [2]. The gene discussed is SERPINC1; the disease is inflammatory bowel disease.