Given XPO1’s involvement in multiple pathways related to colorectal cancer progression, and our in vivo and in vitro evidence demonstrating that eltanexor inhibits a broad range of colorectal cancer cells, we speculate that eltanexor could serve as an effective chemopreventive agent for other individuals who are at a high risk for colorectal cancer. Here, XPO1 is linked to colorectal cancer.