One such compound, MC3935 (Figure ), was recently described byus as a potent human LSD1i with profound effects on , further validating LSD1 as a viable epigenetictarget for treating this parasitic infection., Using in silico techniques, we showed that MC3935 binds to the LSD1 (SmLSD1) catalyticpocket, and knockdown of SmLSD1 by RNAi phenocopiedthe MC3935 effects in adult worms. Treatmentof juvenile and adult worms with MC3935 led to severe tegument damage,impaired egg production, and parasite death within 96 h. Here, KDM1A is linked to parasitic infectious disease.