To further delineate disease-associated immune cell states, we subclustered JIA synovial tissue, SFMC, and PBMC scRNA-seq data more finely, yielding five myeloid, four DC, nine T cell, five NK cell/ILC and nine B/plasma cell states, described on the basis of gene and, where possible, cell surface antigen expression (Fig. 3, A to C, fig. This evidence concerns the gene CD53 and juvenile idiopathic arthritis.