Mutations associated with epilepsy frequently occur in genes that regulate neuronal excitability through ion channels such as voltage-gated ion channels (e.g. K+, Na+, and Ca2+ channels) and ligand-gated ion channels (e.g. nicotinic acetylcholine and GABAA receptors) (Fukata and Fukata, 2017; Noebels, 2015; Steinlein, 2004). Here, GLRA3 is linked to epilepsy.