To further explore the effect of GLP-1 RAs on the ovaries at the cellular level, a study evaluated their impact on granulosa cells from a PCOS mouse model [34] and showed a favorable effect on granulosa cell proliferation (and reducing apoptosis) via forkhead box protein O1 (FoxO1) [34]. The gene discussed is FOXO1; the disease is polycystic ovary syndrome.