For instance, a meta-analysis study of randomized trials compared metformin to GLP-1 RAs in women with PCOS and reported that GLP-1 RAs, in addition to lowering body weight, was significantly better than metformin in improving insulin sensitivity as well as improving menstrual cyclicity, lowering serum total testosterone, lowering total cholesterol, and lowering blood pressure [11]. The gene discussed is INS; the disease is polycystic ovary syndrome.