A meta-analysis of randomized trials (n = 8) compared metformin alone to GLP-1 RA injectables in women with PCOS and showed that that GLP-1 RAs significantly improved insulin resistance, blood pressure, cholesterol and menstrual irregularities as well as lowered weight/abdominal circumference along with androgen indices and hirsutism, in a manner better than metformin alone [11]. This evidence concerns the gene GCG and Insulin resistance.