CDK8 and colorectal cancer: Similarfindings have been reported using orthogonal proteomic profiling approachesin cortistatin A - treated HCT116 colorectal cancer cells, HEK293genetic models, and CDK8/19 double-knockout mouse intestinal cells.−,  These findings included decreased phosphorylation of Mediator complexsubunits, epigenetic regulators, and transcription factors, consistentwith the role of Mediator kinases in regulating transcription.