In contrast to the single knockouts,double knockout clones were completely unresponsive to CCT251921 treatment(T/C: 113 ± 10%, p < 0.005; Figure A), demonstrating that inhibitionof both CDK8 and CDK19 is required to slow or arrest growth in theSW620 colon cancer xenograft model. The gene discussed is CDK8; the disease is malignant colon neoplasm.