Abbreviations: AD, Alzheimer’s disease; BMI, body mass index; CCS, composite cognitive score; CI, confidence interval; CNT, Category Naming Test; Digit Symbol Substitution Test; GDS, Geriatric Depression Scale; IC, intrinsic capacity; MAPT, Multidomain Alzheimer Preventive Trial; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; p-tau 181, phosphorylated-tau 181; PUFA, polyunsaturated fatty acid; Q, quartile; SAS, Statistical Analysis Software; SPPB, Short Physical Performance Battery; WHO, World Health Organization. Here, MAPT is linked to Cognitive impairment.