Our findings are generally consistent with cross-sectional results from NHANES, where higher blood levels of bromodichloromethane and chloroform were associated with lower estimated GFR and dibromochloromethane was associated with a higher urinary albumin-to-creatinine ratio.32 Another NHANES study (1999-2018) showed an association between brominated THMs and hypertension—a frequent comorbidity associated with CKD.68 This evidence concerns the gene ALB and hypertensive disorder.