SLC10A2 and cholestasis: However the changes in kidney BA reabsorption or IBAT expression appear to be variable between different cholestatic models and between species, with fractional tubular taurocholate reabsorption decreasing from 93.1% to 89.5% in bile duct-ligated rats,60 and a range of reported cholestasis-associated decreases in kidney IBAT expression or activity in rats (decreased ~40% to 60%60,61) and wildtype mice (decreased ~0% to 55%;62–67).