SLC10A1 and cholestasis: Despite these experimental caveats, there are multiple attractive features of NTCP/Ntcp inhibition, including the potential to block residual NTCP activity that persists despite adaptive mechanism to reduce NTCP expression/activity, the apparent absence of adverse consequences associated with genetic interruption of NTCP function in human subjects, and unloading the cholestatic hepatocyte is likely to require a multi-pronged approach to tailor the array of therapeutic approaches to the individual patient’s underlying defect and degree of cholestasis (see the Summary section).