In HOCl-induced fibrosis BALB/c mice, BM-MSCs from syngeneic, allogeneic, and xenogeneic (human) donors decreased skin and lung fibrosis, and this effect was not associated with MSC migration to the skin or with long-term survival of MSCs [91] whereas inducible nitric oxide synthase (iNOS) was required for the anti-fibrotic effect of BM-MSCs [92]. The gene discussed is NOS2; the disease is pulmonary fibrosis.