Considering the contradictory relationship between IL‐12 signalling and IFN‐γ dynamics in APAP‐induced hepatotoxicity observed in our studies, we speculate that the use of CLL or IL‐12 inhibitors during APAP‐induced liver injury will lead to a significant decrease in the levels of anti‐inflammatory cytokines such as IL‐10. The gene discussed is IFNG; the disease is B-cell chronic lymphocytic leukemia.