PGP and obesity due to melanocortin 4 receptor deficiency: Notably, hepatic P-gp induction during diet-induced obesity and/or the progression of NAFLD has been reported in several animal models, including the methionine- and choline-deficient diet and atherogenic diet models [46, 47], as well as in patients with NAFLD [48], which is consistent with our results (data not shown).