MTCH2 knockout in zebrafish led to a decrease in the number of adipocytes.[51] MTCH2 promoted lipid accumulation in transgenic MTCH2‐GFP mice by upregulating the levels of lipid metabolism genes such as FASN and SREBP1.[18] Additionally, studies have shown that MTCH2 knockout in mice results in embryonic lethality.[16] In this study, we evaluated for the first time the effects of MTCH2 on the progression of CRC in intestine‐specific MTCH2cKO mice. The gene discussed is SREBF1; the disease is colorectal carcinoma.