MTCH2 and colorectal carcinoma: To investigate the role of MTCH2 in CRC progression, we generated normal colon epithelial NCM460 cells and CRC cells with MTCH2 knockout and overexpression using two single‐guide RNAs (sgRNAs; sgMTCH2#1, sgMTCH2#2) and an expression plasmid (Flag‐MTCH2), respectively.