The outer mitochondrial protein MTCH2 (SLC25A50) is a member of the solute carrier family and is critical for mitochondrial metabolism, apoptosis, and stem cell differentiation.[15, 16, 17] Accumulating evidence has demonstrated that changes in MTCH2 levels can lead to various health conditions, including obesity, Alzheimer's disease, and embryological developmental anomalies.[18, 19, 20] Guna et al. Here, MTCH2 is linked to early-onset autosomal dominant Alzheimer disease.