In addition to its role in tumor progression, increasing evidence demonstrates that ferroptosis is also implicated in diseases of other systems, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.[7, 46] Interestingly, previous studies have demonstrated that MTCH2 deficiency impairs the activity of neuronal cells and accelerates neurodegeneration,[47, 48] together with our findings on the E2F4‐TFRC axis in MTCH2‐associated ferroptosis. Here, MTCH2 is linked to neurodegenerative disease.