A recent study by Guo reported that MTCH2 suppresses ferroptosis by regulating mitochondrial permeability transition, highlighting its role in modulating pore dynamics at the organelle level.[45] Our findings uncover a distinct transcriptional mechanism through which the MTCH2/E2F4/TFRC axis promotes CRC progression supported by in vivo evidence from intestine‐specific MTCH2cKO mice. Here, E2F4 is linked to colorectal carcinoma.