Oral squamous cell carcinoma usually secretes chemokine CXCL8 to attract dental pulp MSCs; the presence of MSCs' membrane enables biomimetic nanodrugs to accumulate in oral squamous cell carcinoma in vitro and in vivo via CXCL8/CXCR2 signaling pathway.[80] It is well known that cells obtain a series of functional capabilities during the carcinogenic transformation; these alterations involve maintaining proliferative signaling, facilitating replicative immortality, counteracting cell death, and evading immune destruction. This evidence concerns the gene CXCR2 and oral cavity squamous cell carcinoma.