For example, lemon‐derived PEVs isolated from lemon juice have been shown to upregulate the GADD45a gene through the production of ROS, leading to the S‐phase arrest and apoptosis of gastric cancer cell cycle, thus exerting anti‐gastric cancer activities in vitro and in vivo.[133] Xiao et al. The gene discussed is GADD45A; the disease is gastric cancer.