Moreover, Brucea javanica‐derived PEVs were shown to inhibit the secretion of vascular endothelial growth factor and regulate the biological functions of vascular endothelial cells, which suppressed angiogenesis in the TME, ultimately inhibiting tumor metastasis and angiogenesis in 4T1 tumor‐bearing mice.[126] Wang et al. This evidence concerns the gene VEGFA and neoplasm.