PRF1 and neoplasm: Moreover, distinct from T lymphocytes, NKs without antigen pre‐sensitization could lyse tumor cells through the exocytosis pathways of granzyme B and perforin, as well as provoke tumor necrosis via the Fas ligand or tumor necrosis factor‐related apoptosis‐inducing ligand.[75] Considering this, NK‐based antitumor monotherapy or in combination with gene manipulation approaches like genetic modification and chimeric antigen receptor engineering have been broadly investigated because of their remarkable antitumor effectiveness in pre‐clinical and clinical studies.[76] Deng et al.