For example, one study found that meningeal lymphatic morphology and function was not altered relative to control in the APeD9 and 5xFAD mouse models of AD, and although manipulating VEGF-C levels and signaling in these mice led to expected changes in meningeal lymphatics coverage and drainage function to cervical lymphatics nodes, it failed to have an impact on amyloid plaque accumulation or behavioral AD-like phenotypes (Antila et al., 2024). The gene discussed is VEGFC; the disease is Alzheimer disease.