Surprisingly, Lyve1 staining density per ALS EDL cross-section was not different from that in NC control EDL (Fig. 7C), despite the muscle having higher Lyve1 protein levels overall (Fig. 5B) (NC, 0.534±0.043%; ALS, 0.499±0.071%; P=0.6875). Here, LYVE1 is linked to amyotrophic lateral sclerosis.