Vegfc is essential for the formation of peripheral (Karkkainen et al., 2004) and meningeal lymphatics during development (Antila et al., 2017), and the fact that its expression is unaltered in the ALS mice may account for the minimal changes in lymphatic capillary coverage we report in postsymptomatic SPC and muscle. Here, VEGFC is linked to amyotrophic lateral sclerosis.