For instance, differential exon inclusion in the amyloid precursor protein (APP) influences Aß peptide production (Raj et al., 2018), while the MAPT gene’s 3 R/4 R tau isoform balance is central to tauopathy pathogenesis; an instability in these isoforms is a characteristics of AD pathology (Daoud, 2012). Here, APP is linked to Alzheimer disease.