LGALS3 and neoplasm: When Panc-1 cells and HPSCs were co-cultured with or without Gal-3, we discovered that HPSCs could increase the number of tumor spheres by twofold in comparison with the situation in which Panc-1 cells were treated with gemcitabine alone, and that the number of HPSCs genetically expressing Gal-3 could further double the number of tumor spheres in contrast to HPSCs alone (Fig. 5C).