This study provides a potentially effective anti-cancer strategy for prostate cancer gene therapy (85); Prostate cancer development is also associated with other epigenetic regulation, in terms of DNA methylation and demethylation, DNMT1 has oncogenic activity in the early stage of prostate cancer, while it has oncogenic activity in the late stage, promoting metastasis by inducing epithelial-mesenchymal transition and a cancer stem cell phenotype. This evidence concerns the gene DNMT1 and Familial prostate cancer.