In terms of histone modification, JMJD1A, as a key coactivator of AR, is epigenetic genetic regulation H3K9 methylation recruits Heterogeneous Nuclear Ribonucleoprotein F (HNRNPF) to promote variable splicing of AR-V7, and silencing of JMJD1A reduces AR-V7 levels; JMJD2A drives prostate carcinogenesis through the transcription factor ETS Variant Transcription Factor 1 (ETV1). The gene discussed is KDM3A; the disease is prostatitis.