A research team has reconstructed the dCas9-HDAC8-EGFP fusion and performed histone deacetylation of the promoters of ESR1 (EStrogen Receptor 1), TERT (Telomerase reverse transcriptase), and CDKN1C (Cyclin-dependent kinase inhibitor 1C) genes in cancer cell lines MCF-7 (Michigan Cancer Foundation-7), and MDA-MB-231 (M D Anderson—Metastatic Breast—231), and HEK 293 (Human embryonic kidney 293) cells. This evidence concerns the gene CDKN1C and cancer.