GAD2 and epilepsy: In rodent models, increased choline intake during gestation and early postnatal development has been demonstrated to protect the brain from epilepsy-related neurological damage, likely by reducing compensatory cell proliferation in the dentate gyrus (Wong-Goodrich et al., 2008), preventing the loss of GAD65 mRNA in the hippocampus (which encodes a form of the GABA-synthesizing enzyme) (Wong-Goodrich et al., 2008), and increasing the levels of trophic factors in the hippocampus (Ricceri et al., 2011).