Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by pathogenic variants in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6, PMS2, and, occasionally, EPCAM (1). This evidence concerns the gene EPCAM and hereditary nonpolyposis colon cancer.