PFKFB3 and diabetes mellitus: Mice with streptozotocin (STZ)-induced diabetes had significantly higher PFKFB3 expression in pancreatic beta cells than control-treated mice (p <0.001), which was significantly inhibited by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), a glycolysis inhibitor (p <0.001; Figures 6A, B).