FLOT1 and systemic lupus erythematosus: Notably, FLOT1 was significantly upregulated in SLE platelets (Figure 5b) and was positively correlated with these immune–inflammatory pathways (Figure 5g and Table S8), suggesting that FLOT1 may be involved in platelet-mediated immune responses and signal transduction, thereby contributing to the pathogenesis of SLE (Figure 7).