RAC1 and cancer: RAC1, as a key regulator of the actin cytoskeleton, initiates actin filament reorganization, resulting in the formation of cellular protrusions (filopodium-like protrusion), enhanced cell migration, and increased invasive capacity of cancer cells A third possible pathway by which NET formation can promote cancer metastasis was described by Albrengues and colleagues who showed that inflammation-stimulated NET formation can awaken dormant cancer cells (10).