Hippo signaling is suppressed in alveolar RMS cell lines and tumors (150), and genetically inhibiting the Hippo/MST signaling by knocking out kinases MST1 and MST2 (Stk4, Stk3), led to more rapid Pax3::Foxo1 tumor onset and higher penetrance. The gene discussed is FOXO1; the disease is neoplasm.