The therapy was well tolerated with the predominant grade I to IV AEs including hypertension (2/16), fatigue (3/16), oral mucositis (1/16), anorexia (3/16), joint/muscle pain (2/16), and hand–foot syndrome (1/16), alanine aminotransferase (ALT) increased (2/16), aspartate transaminase (AST) increased, total bilirubin increased (1/16), direct bilirubin increased(1/16), and proteinuria (1/16) (Table 3). This evidence concerns the gene GPT and Hypertension.